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Normalizing single cell RNA sequencing data — Pitfalls and Recommendations

From towards data science by Shivangi Patel The goals of a single cell RNA sequencing (scRNA-seq) project are often Identification of subpopulations and Differential Gene Expression Analysis. To avoid the ‘curse of dimensionality’, Highly Variable Genes (HVGs) are used for cluster analysis. Several studies have shown that selection of HVGs is sensitive to the choice ...

Study provides first look at sperm microbiome using RNA sequencing sensitive enough to detect bacteria

A new collaborative study published by a research team from the Wayne State University School of Medicine, the CReATe Fertility Centre and the University of Massachusetts Amherst provides the first in-depth look at the microbiome of human sperm utilizing RNA sequencing with sufficient sensitivity to identify contamination and pathogenic bacterial colonization. “We show that non-targeted ...

First in-depth analysis of primate ovarian aging at single-cell resolution

Due to the modern tendency to postpone childbirth until later in life, a growing number of women are experiencing issues with infertility.

Roche Diagnostics Keeps Eyes Firmly on China

MolDx Finalizes Expanded Coverage for Liquid Biopsies

Atila Biosystems High-Throughput Isothermal HPV Test Validated in Study

Illumina Puts Spotlight on Clinical NGS Opportunities, Cites Contributions to Coronavirus Response

Lung Cancer Liquid Biopsy Study Shows Potential of MRD-Directed Adjuvant Therapy